Drug interactions
Armodafinil + Fosaprepitant
Severity: Minor
Armodafinil and Fosaprepitant: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fosaprepitant is converted to aprepitant, a CYP3A4 substrate. Armodafinil's weak CYP3A4 induction might reduce aprepitant exposure, but fosaprepitant is given as a single dose, so the effect is likely small.
What this interaction means in plain words
Armodafinil and Fosaprepitant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Armodafinil belongs to Central Nervous System; Fosaprepitant belongs to Gastrointestinal Tract.
Why it happens
Weak CYP3A4 induction by armodafinil may increase aprepitant metabolism.
What to do
No dose change is usually needed. Watch for breakthrough nausea and vomiting and add rescue antiemetics if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Armodafinil
Other interactions of Fosaprepitant
- Flibanserin + Fosaprepitant Contraindicated
- Fosaprepitant + Pimozide Contraindicated
- Alprazolam + Fosaprepitant Moderate
- Amiodarone + Fosaprepitant Moderate
- Amobarbital + Fosaprepitant Moderate
- Apalutamide + Fosaprepitant Moderate
Frequently asked questions
Can I take Armodafinil with Fosaprepitant?
MediHelp rates the interaction as minor. Armodafinil and Fosaprepitant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fosaprepitant is converted to aprepitant, a CYP3A4 substrate. Armodafinil's weak CYP3A4 induction might reduce aprepitant exposure, but fosaprepitant is given as a single dose, so the effect is likely small.
How serious is the interaction between Armodafinil and Fosaprepitant?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed. Watch for breakthrough nausea and vomiting and add rescue antiemetics if needed.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
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