Drug interactions
Armodafinil + Hydromorphone
Severity: Minor
Armodafinil and Hydromorphone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Armodafinil is a wakefulness-promoting agent and does not reliably reverse opioid-induced respiratory depression. Its effect on hydromorphone sedation is unclear and no clinically important interaction is established.
What this interaction means in plain words
Armodafinil and Hydromorphone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Armodafinil belongs to Central Nervous System; Hydromorphone belongs to Musculoskeletal.
Why it happens
Opposing CNS effects; no established pharmacokinetic interaction with hydromorphone.
What to do
No dose change is needed. Do not rely on armodafinil to offset opioid sedation, and monitor respiratory status as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydromorphone
- Alvimopan + Hydromorphone Contraindicated
- Bupropion-naltrexone + Hydromorphone Contraindicated
- Hydromorphone + Isocarboxazid Contraindicated
- Hydromorphone + Olanzapine / samidorphan Contraindicated
- Hydromorphone + Phenelzine Contraindicated
- Hydromorphone + Tranylcypromine Contraindicated
Other interactions of Armodafinil
Frequently asked questions
Can I take Armodafinil with Hydromorphone?
MediHelp rates the interaction as minor. Armodafinil and Hydromorphone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Armodafinil is a wakefulness-promoting agent and does not reliably reverse opioid-induced respiratory depression. Its effect on hydromorphone sedation is unclear and no clinically important interaction is established.
How serious is the interaction between Armodafinil and Hydromorphone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed. Do not rely on armodafinil to offset opioid sedation, and monitor respiratory status as usual.
What other medicines interact with Hydromorphone?
MediHelp also lists interactions of Hydromorphone with, for example, Alvimopan, Bupropion-naltrexone, Isocarboxazid. The full list is on the Hydromorphone page.
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