Drug interactions
Armodafinil + Hydroxyzine
Severity: Minor
Armodafinil and Hydroxyzine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydroxyzine is a sedating antihistamine and armodafinil promotes wakefulness. The opposing effects may blunt the benefit of armodafinil and make alertness unpredictable.
What this interaction means in plain words
Armodafinil and Hydroxyzine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Armodafinil belongs to Central Nervous System; Hydroxyzine belongs to Respiratory.
Why it happens
Opposing pharmacodynamic effects on CNS arousal.
What to do
Monitor alertness and consider a non-sedating alternative if sedation undermines armodafinil therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Armodafinil
Other interactions of Hydroxyzine
- Droperidol + Hydroxyzine Contraindicated
- Hydroxyzine + Pimozide Contraindicated
- Hydroxyzine + Thioridazine Contraindicated
- Hydroxyzine + Vandetanib Contraindicated
- Alfentanil + Hydroxyzine Major
- Amiodarone + Hydroxyzine Major
Frequently asked questions
Can I take Armodafinil with Hydroxyzine?
MediHelp rates the interaction as minor. Armodafinil and Hydroxyzine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydroxyzine is a sedating antihistamine and armodafinil promotes wakefulness. The opposing effects may blunt the benefit of armodafinil and make alertness unpredictable.
How serious is the interaction between Armodafinil and Hydroxyzine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor alertness and consider a non-sedating alternative if sedation undermines armodafinil therapy.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
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