Drug interactions
Armodafinil + Iloperidone
Severity: Moderate
Armodafinil and Iloperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Armodafinil may lower iloperidone exposure through weak CYP3A4 induction, potentially reducing antipsychotic effect. Their CNS effects also oppose each other, since iloperidone is sedating and armodafinil promotes wakefulness.
What this interaction means in plain words
Armodafinil and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Armodafinil belongs to Central Nervous System; Iloperidone belongs to Central Nervous System.
Why it happens
Weak CYP3A4 induction by armodafinil increases iloperidone metabolism, with opposing CNS pharmacodynamics.
What to do
Monitor psychiatric symptoms for loss of control and adjust the iloperidone dose if needed. Review sedation and alertness on starting or stopping armodafinil.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Armodafinil
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Armodafinil with Iloperidone?
MediHelp rates the interaction as moderate. Armodafinil and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Armodafinil may lower iloperidone exposure through weak CYP3A4 induction, potentially reducing antipsychotic effect. Their CNS effects also oppose each other, since iloperidone is sedating and armodafinil promotes wakefulness.
How serious is the interaction between Armodafinil and Iloperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor psychiatric symptoms for loss of control and adjust the iloperidone dose if needed. Review sedation and alertness on starting or stopping armodafinil.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
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