Drug interactions
Armodafinil + Itraconazole
Severity: Minor
Armodafinil and Itraconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole may modestly increase armodafinil exposure. This could enhance adverse effects such as headache, anxiety, insomnia and raised blood pressure.
What this interaction means in plain words
Armodafinil and Itraconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Armodafinil belongs to Central Nervous System; Itraconazole belongs to Anti Fungals.
Why it happens
Itraconazole inhibits CYP3A4, a minor elimination pathway for armodafinil.
What to do
No dose change is usually needed. Monitor for increased stimulant effects and blood pressure.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Other interactions of Armodafinil
Frequently asked questions
Can I take Armodafinil with Itraconazole?
MediHelp rates the interaction as minor. Armodafinil and Itraconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Itraconazole may modestly increase armodafinil exposure. This could enhance adverse effects such as headache, anxiety, insomnia and raised blood pressure.
How serious is the interaction between Armodafinil and Itraconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed. Monitor for increased stimulant effects and blood pressure.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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