Drug interactions
Armodafinil + Ivacaftor
Severity: Moderate
Armodafinil and Ivacaftor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Armodafinil is a weak CYP3A4 inducer, so it would be expected to lower rather than raise ivacaftor concentrations. Reduced exposure could diminish CFTR modulation and clinical benefit.
What this interaction means in plain words
Armodafinil and Ivacaftor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Armodafinil belongs to Central Nervous System; Ivacaftor belongs to Miscellaneous.
Why it happens
Weak CYP3A4 induction by armodafinil may increase ivacaftor metabolism.
What to do
Monitor respiratory function and clinical response to ivacaftor, and consider an alternative to armodafinil if efficacy falls.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Armodafinil
Other interactions of Ivacaftor
- Ensitrelvir + Ivacaftor Contraindicated
- Apalutamide + Ivacaftor Major
- Carbamazepine + Ivacaftor Major
- Clarithromycin + Ivacaftor Major
- Efavirenz + Ivacaftor Major
- Enzalutamide + Ivacaftor Major
Frequently asked questions
Can I take Armodafinil with Ivacaftor?
MediHelp rates the interaction as moderate. Armodafinil and Ivacaftor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Armodafinil is a weak CYP3A4 inducer, so it would be expected to lower rather than raise ivacaftor concentrations. Reduced exposure could diminish CFTR modulation and clinical benefit.
How serious is the interaction between Armodafinil and Ivacaftor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor respiratory function and clinical response to ivacaftor, and consider an alternative to armodafinil if efficacy falls.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
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