Drug interactions
Armodafinil + Lomitapide
Severity: Moderate
Armodafinil and Lomitapide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lomitapide is a sensitive CYP3A4 substrate, and armodafinil, a weak CYP3A4 inducer, would be expected to lower its exposure rather than raise it. Reduced lomitapide exposure could blunt LDL-lowering efficacy.
What this interaction means in plain words
Armodafinil and Lomitapide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Armodafinil belongs to Central Nervous System; Lomitapide belongs to Cardiovascular.
Why it happens
Weak CYP3A4 induction by armodafinil increases lomitapide metabolism.
What to do
Monitor LDL cholesterol after starting or stopping armodafinil and titrate lomitapide as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Armodafinil
Other interactions of Lomitapide
- Aprepitant + Lomitapide Contraindicated
- Clarithromycin + Lomitapide Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Efavirenz + Lomitapide Contraindicated
- Ensitrelvir + Lomitapide Contraindicated
Frequently asked questions
Can I take Armodafinil with Lomitapide?
MediHelp rates the interaction as moderate. Armodafinil and Lomitapide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lomitapide is a sensitive CYP3A4 substrate, and armodafinil, a weak CYP3A4 inducer, would be expected to lower its exposure rather than raise it. Reduced lomitapide exposure could blunt LDL-lowering efficacy.
How serious is the interaction between Armodafinil and Lomitapide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor LDL cholesterol after starting or stopping armodafinil and titrate lomitapide as needed.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
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