Drug interactions
Armodafinil + Lurasidone
Severity: Moderate
Armodafinil and Lurasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Armodafinil is a weak to moderate CYP3A4 inducer and may lower lurasidone concentrations, potentially reducing antipsychotic efficacy. The effect emerges with sustained co-administration.
What this interaction means in plain words
Armodafinil and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Armodafinil belongs to Central Nervous System; Lurasidone belongs to Central Nervous System.
Why it happens
Induction of CYP3A4 increases the metabolism of lurasidone.
What to do
Monitor for loss of psychiatric symptom control after about a week of combined use and increase the lurasidone dose if needed; reduce it again if armodafinil is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Armodafinil
Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Frequently asked questions
Can I take Armodafinil with Lurasidone?
MediHelp rates the interaction as moderate. Armodafinil and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Armodafinil is a weak to moderate CYP3A4 inducer and may lower lurasidone concentrations, potentially reducing antipsychotic efficacy. The effect emerges with sustained co-administration.
How serious is the interaction between Armodafinil and Lurasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of psychiatric symptom control after about a week of combined use and increase the lurasidone dose if needed; reduce it again if armodafinil is stopped.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
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