Drug interactions
Armodafinil + Macimorelin
Severity: Moderate
Armodafinil and Macimorelin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Armodafinil may lower macimorelin exposure through CYP3A4 induction. This could blunt the growth hormone response and produce a false positive result in the growth hormone deficiency stimulation test.
What this interaction means in plain words
Armodafinil and Macimorelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Armodafinil belongs to Central Nervous System; Macimorelin belongs to Endocrine.
Why it happens
CYP3A4 induction by armodafinil increases the metabolism of macimorelin, a CYP3A4 substrate.
What to do
Stop armodafinil with enough washout time before macimorelin testing, if clinically feasible. Otherwise interpret a low growth hormone response cautiously and consider another testing method.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Armodafinil
Other interactions of Macimorelin
Frequently asked questions
Can I take Armodafinil with Macimorelin?
MediHelp rates the interaction as moderate. Armodafinil and Macimorelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Armodafinil may lower macimorelin exposure through CYP3A4 induction. This could blunt the growth hormone response and produce a false positive result in the growth hormone deficiency stimulation test.
How serious is the interaction between Armodafinil and Macimorelin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Stop armodafinil with enough washout time before macimorelin testing, if clinically feasible. Otherwise interpret a low growth hormone response cautiously and consider another testing method.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
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