Drug interactions
Armodafinil + Meperidine
Severity: Minor
Armodafinil and Meperidine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Armodafinil is a wakefulness-promoting agent and may counteract some sedation from meperidine, but it does not reverse respiratory depression. Armodafinil also weakly induces CYP3A4, which could modestly lower exposure to some opioids.
What this interaction means in plain words
Armodafinil and Meperidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Armodafinil belongs to Central Nervous System; Meperidine belongs to Musculoskeletal.
Why it happens
Opposing CNS effects, and weak CYP3A4 induction by armodafinil that may slightly reduce meperidine levels.
What to do
No dose change is routinely needed. Do not rely on armodafinil to prevent opioid-induced respiratory depression, and monitor pain control.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Meperidine
- Alvimopan + Meperidine Contraindicated
- Isocarboxazid + Meperidine Contraindicated
- Meperidine + Methylene blue Contraindicated
- Meperidine + Olanzapine / samidorphan Contraindicated
- Meperidine + Phenelzine Contraindicated
- Meperidine + Procarbazine Contraindicated
Other interactions of Armodafinil
Frequently asked questions
Can I take Armodafinil with Meperidine?
MediHelp rates the interaction as minor. Armodafinil and Meperidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Armodafinil is a wakefulness-promoting agent and may counteract some sedation from meperidine, but it does not reverse respiratory depression. Armodafinil also weakly induces CYP3A4, which could modestly lower exposure to some opioids.
How serious is the interaction between Armodafinil and Meperidine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is routinely needed. Do not rely on armodafinil to prevent opioid-induced respiratory depression, and monitor pain control.
What other medicines interact with Meperidine?
MediHelp also lists interactions of Meperidine with, for example, Alvimopan, Isocarboxazid, Methylene blue. The full list is on the Meperidine page.
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