Drug interactions
Armodafinil + Midazolam
Severity: Minor
Armodafinil and Midazolam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Armodafinil is a weak to moderate CYP3A4 inducer and may reduce midazolam exposure, particularly with oral dosing. Its wakefulness-promoting action may also partly offset sedation, so the net effect is variable.
What this interaction means in plain words
Armodafinil and Midazolam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Armodafinil belongs to Central Nervous System; Midazolam belongs to Central Nervous System.
Why it happens
Weak CYP3A4 induction by armodafinil increases midazolam metabolism.
What to do
Titrate midazolam to clinical effect, anticipating that higher doses may occasionally be needed. No routine dose change is required.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Other interactions of Armodafinil
Frequently asked questions
Can I take Armodafinil with Midazolam?
MediHelp rates the interaction as minor. Armodafinil and Midazolam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Armodafinil is a weak to moderate CYP3A4 inducer and may reduce midazolam exposure, particularly with oral dosing. Its wakefulness-promoting action may also partly offset sedation, so the net effect is variable.
How serious is the interaction between Armodafinil and Midazolam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate midazolam to clinical effect, anticipating that higher doses may occasionally be needed. No routine dose change is required.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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