Drug interactions
Armodafinil + Ospemifene
Severity: Minor
Armodafinil and Ospemifene: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Armodafinil inhibits CYP2C19 and ospemifene is metabolised by CYP2C19 and CYP3A4. Ospemifene exposure may rise through CYP2C19 inhibition, but induction of CYP3A4 could have a competing effect, so the net result is uncertain.
What this interaction means in plain words
Armodafinil and Ospemifene have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Armodafinil belongs to Central Nervous System; Ospemifene belongs to Endocrine.
Why it happens
Armodafinil inhibits CYP2C19 and induces CYP3A4, with an uncertain net effect on ospemifene exposure.
What to do
Monitor for ospemifene adverse effects such as hot flushes and thromboembolic symptoms, and for reduced efficacy. No empiric dose change is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Armodafinil
Other interactions of Ospemifene
- Bazedoxifene-conjugated estrogens + Ospemifene Contraindicated
- Estradiol + Ospemifene Contraindicated
- Clomiphene + Ospemifene Major
- Fluconazole + Ospemifene Major
- Ketoconazole + Ospemifene Major
- Ospemifene + Raloxifene Major
Frequently asked questions
Can I take Armodafinil with Ospemifene?
MediHelp rates the interaction as minor. Armodafinil and Ospemifene have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Armodafinil inhibits CYP2C19 and ospemifene is metabolised by CYP2C19 and CYP3A4. Ospemifene exposure may rise through CYP2C19 inhibition, but induction of CYP3A4 could have a competing effect, so the net result is uncertain.
How serious is the interaction between Armodafinil and Ospemifene?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for ospemifene adverse effects such as hot flushes and thromboembolic symptoms, and for reduced efficacy. No empiric dose change is needed.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
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