Drug interactions
Armodafinil + Phentermine
Severity: Moderate
Armodafinil and Phentermine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Armodafinil and phentermine are both stimulants. Taken together they may add to sympathomimetic effects such as raised heart rate and blood pressure, nervousness, insomnia and anxiety.
What this interaction means in plain words
Armodafinil and Phentermine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Armodafinil belongs to Central Nervous System; Phentermine belongs to Central Nervous System.
Why it happens
Additive central nervous system and sympathomimetic stimulation.
What to do
Monitor blood pressure, heart rate and sleep or anxiety symptoms when starting the combination. Reduce a dose or stop one agent if cardiovascular or CNS stimulation becomes troublesome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Armodafinil
Other interactions of Phentermine
- Isocarboxazid + Phentermine Contraindicated
- Linezolid + Phentermine Contraindicated
- Phenelzine + Phentermine Contraindicated
- Phentermine + Procarbazine Contraindicated
- Phentermine + Rasagiline Contraindicated
- Phentermine + Selegiline Contraindicated
Frequently asked questions
Can I take Armodafinil with Phentermine?
MediHelp rates the interaction as moderate. Armodafinil and Phentermine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Armodafinil and phentermine are both stimulants. Taken together they may add to sympathomimetic effects such as raised heart rate and blood pressure, nervousness, insomnia and anxiety.
How serious is the interaction between Armodafinil and Phentermine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and sleep or anxiety symptoms when starting the combination. Reduce a dose or stop one agent if cardiovascular or CNS stimulation becomes troublesome.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
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