Drug interactions
Armodafinil + Promethazine
Severity: Minor
Armodafinil and Promethazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Armodafinil promotes wakefulness whereas promethazine causes sedation, so their effects may partly oppose each other. The clinical result is unpredictable and no important interaction is well established.
What this interaction means in plain words
Armodafinil and Promethazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Armodafinil belongs to Central Nervous System; Promethazine belongs to Respiratory.
Why it happens
Opposing CNS effects; no established pharmacokinetic mechanism of significance.
What to do
No dose change needed; monitor alertness and counsel that sedation from promethazine may persist.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Promethazine
- Cabergoline + Promethazine Contraindicated
- Dopamine + Promethazine Contraindicated
- Ibutilide + Promethazine Contraindicated
- Pimozide + Promethazine Contraindicated
- Promethazine + Thioridazine Contraindicated
- Alfentanil + Promethazine Major
Other interactions of Armodafinil
Frequently asked questions
Can I take Armodafinil with Promethazine?
MediHelp rates the interaction as minor. Armodafinil and Promethazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Armodafinil promotes wakefulness whereas promethazine causes sedation, so their effects may partly oppose each other. The clinical result is unpredictable and no important interaction is well established.
How serious is the interaction between Armodafinil and Promethazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change needed; monitor alertness and counsel that sedation from promethazine may persist.
What other medicines interact with Promethazine?
MediHelp also lists interactions of Promethazine with, for example, Cabergoline, Dopamine, Ibutilide. The full list is on the Promethazine page.
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