Drug interactions
Armodafinil + Ribociclib
Severity: Minor
Armodafinil and Ribociclib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib is a CYP3A4 inhibitor and may raise armodafinil concentrations. Increased armodafinil exposure could cause more insomnia, anxiety, headache or palpitations.
What this interaction means in plain words
Armodafinil and Ribociclib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Armodafinil belongs to Central Nervous System; Ribociclib belongs to Oncology.
Why it happens
Ribociclib inhibits CYP3A4 and may reduce armodafinil clearance.
What to do
Monitor for stimulant-related adverse effects such as insomnia, anxiety and increased heart rate. Reduce the armodafinil dose if they occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Armodafinil
Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Armodafinil with Ribociclib?
MediHelp rates the interaction as minor. Armodafinil and Ribociclib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ribociclib is a CYP3A4 inhibitor and may raise armodafinil concentrations. Increased armodafinil exposure could cause more insomnia, anxiety, headache or palpitations.
How serious is the interaction between Armodafinil and Ribociclib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for stimulant-related adverse effects such as insomnia, anxiety and increased heart rate. Reduce the armodafinil dose if they occur.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
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