Drug interactions
Armodafinil + Sirolimus
Severity: Moderate
Armodafinil and Sirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Armodafinil may reduce sirolimus concentrations and weaken immunosuppression, risking rejection in transplant recipients. The effect is typically smaller than with strong inducers.
What this interaction means in plain words
Armodafinil and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Armodafinil belongs to Central Nervous System; Sirolimus belongs to Miscellaneous.
Why it happens
Armodafinil induces CYP3A4 and may affect intestinal metabolism, increasing sirolimus clearance.
What to do
Monitor sirolimus trough levels after starting or stopping armodafinil and adjust the dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Armodafinil
Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Frequently asked questions
Can I take Armodafinil with Sirolimus?
MediHelp rates the interaction as moderate. Armodafinil and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Armodafinil may reduce sirolimus concentrations and weaken immunosuppression, risking rejection in transplant recipients. The effect is typically smaller than with strong inducers.
How serious is the interaction between Armodafinil and Sirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sirolimus trough levels after starting or stopping armodafinil and adjust the dose accordingly.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
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