Drug interactions
Armodafinil + Tacrolimus
Severity: Moderate
Armodafinil and Tacrolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Armodafinil may lower tacrolimus blood concentrations through CYP3A4 induction, which could increase the risk of rejection in transplant recipients due to subtherapeutic exposure.
What this interaction means in plain words
Armodafinil and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Armodafinil belongs to Central Nervous System; Tacrolimus belongs to Miscellaneous.
Why it happens
Induction of CYP3A4 and intestinal metabolism of tacrolimus.
What to do
Measure tacrolimus trough levels after starting or stopping armodafinil and adjust the dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Armodafinil
Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Armodafinil with Tacrolimus?
MediHelp rates the interaction as moderate. Armodafinil and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Armodafinil may lower tacrolimus blood concentrations through CYP3A4 induction, which could increase the risk of rejection in transplant recipients due to subtherapeutic exposure.
How serious is the interaction between Armodafinil and Tacrolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Measure tacrolimus trough levels after starting or stopping armodafinil and adjust the dose accordingly.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
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