Drug interactions
Armodafinil + Tazemetostat
Severity: Moderate
Armodafinil and Tazemetostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tazemetostat is a CYP3A4 substrate, so armodafinil may lower its exposure and reduce efficacy. Tazemetostat is itself a weak CYP3A4 inducer, which might slightly reduce armodafinil levels.
What this interaction means in plain words
Armodafinil and Tazemetostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Armodafinil belongs to Central Nervous System; Tazemetostat belongs to Miscellaneous.
Why it happens
Bidirectional CYP3A4 induction affecting metabolism of both drugs.
What to do
Monitor oncologic response and armodafinil effect. Avoid strong inducers with tazemetostat; weak inducers need monitoring only.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Armodafinil
Other interactions of Tazemetostat
Frequently asked questions
Can I take Armodafinil with Tazemetostat?
MediHelp rates the interaction as moderate. Armodafinil and Tazemetostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tazemetostat is a CYP3A4 substrate, so armodafinil may lower its exposure and reduce efficacy. Tazemetostat is itself a weak CYP3A4 inducer, which might slightly reduce armodafinil levels.
How serious is the interaction between Armodafinil and Tazemetostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor oncologic response and armodafinil effect. Avoid strong inducers with tazemetostat; weak inducers need monitoring only.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
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