Drug interactions
Armodafinil + Temazepam
Severity: Minor
Armodafinil and Temazepam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Temazepam is a sedative-hypnotic and armodafinil promotes wakefulness, so each may blunt the other's intended effect. Armodafinil may mask sedation without eliminating psychomotor impairment.
What this interaction means in plain words
Armodafinil and Temazepam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Armodafinil belongs to Central Nervous System; Temazepam belongs to Central Nervous System.
Why it happens
Opposing pharmacodynamic CNS effects; temazepam is conjugated, so no meaningful CYP interaction.
What to do
Counsel on residual impairment when driving. Review the need for both drugs if sleep or daytime alertness problems persist.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Armodafinil
Other interactions of Temazepam
- Alprazolam + Temazepam Major
- Amobarbital + Temazepam Major
- Buprenorphine + Temazepam Major
- Butorphanol + Temazepam Major
- Carisoprodol + Temazepam Major
- Chloral hydrate + Temazepam Major
Frequently asked questions
Can I take Armodafinil with Temazepam?
MediHelp rates the interaction as minor. Armodafinil and Temazepam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Temazepam is a sedative-hypnotic and armodafinil promotes wakefulness, so each may blunt the other's intended effect. Armodafinil may mask sedation without eliminating psychomotor impairment.
How serious is the interaction between Armodafinil and Temazepam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel on residual impairment when driving. Review the need for both drugs if sleep or daytime alertness problems persist.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
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