Drug interactions
Armodafinil + Tizanidine
Severity: Minor
Armodafinil and Tizanidine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Armodafinil is a weak inducer of CYP3A4 and may have a minor effect on CYP1A2, so any reduction in tizanidine exposure is likely small. Clinically significant loss of tizanidine effect is uncertain.
What this interaction means in plain words
Armodafinil and Tizanidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Armodafinil belongs to Central Nervous System; Tizanidine belongs to Musculoskeletal.
Why it happens
Possible weak CYP1A2 induction by armodafinil; the effect is not well established.
What to do
No routine change is needed. Monitor spasticity control and adjust the tizanidine dose if response is reduced.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Armodafinil and Tizanidine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Tizanidine
- Ciprofloxacin + Tizanidine Contraindicated
- Fluvoxamine + Tizanidine Contraindicated
- Pefloxacin + Tizanidine Contraindicated
- Pipemidic acid + Tizanidine Contraindicated
- Benzhydrocodone / acetaminophen + Tizanidine Major
- Brexanolone + Tizanidine Major
Other interactions of Armodafinil
Frequently asked questions
Can I take Armodafinil with Tizanidine?
MediHelp rates the interaction as minor. Armodafinil and Tizanidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Armodafinil is a weak inducer of CYP3A4 and may have a minor effect on CYP1A2, so any reduction in tizanidine exposure is likely small. Clinically significant loss of tizanidine effect is uncertain.
How serious is the interaction between Armodafinil and Tizanidine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed. Monitor spasticity control and adjust the tizanidine dose if response is reduced.
What other medicines interact with Tizanidine?
MediHelp also lists interactions of Tizanidine with, for example, Ciprofloxacin, Fluvoxamine, Pefloxacin. The full list is on the Tizanidine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
