Drug interactions
Arsenic trioxide + Dasatinib
Severity: Major
Arsenic trioxide and Dasatinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, and arsenic trioxide carries a boxed warning for QT prolongation and torsades de pointes. Combined use raises the risk of serious ventricular arrhythmias, particularly with electrolyte disturbances.
What this interaction means in plain words
Arsenic trioxide and Dasatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Arsenic trioxide belongs to Oncology; Dasatinib belongs to Oncology.
Why it happens
Additive pharmacodynamic QT prolongation through cardiac repolarization effects.
What to do
Avoid the combination where possible; if unavoidable, obtain a baseline ECG and correct potassium and magnesium before starting. Monitor ECG and electrolytes regularly throughout treatment.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Other interactions of Arsenic trioxide
- Amiodarone + Arsenic trioxide Contraindicated
- Amisulpride + Arsenic trioxide Contraindicated
- Arsenic trioxide + Clomipramine Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Arsenic trioxide + Fluphenazine Contraindicated
- Arsenic trioxide + Gemifloxacin Contraindicated
Frequently asked questions
Can I take Arsenic trioxide with Dasatinib?
MediHelp rates the interaction as major. Arsenic trioxide and Dasatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QT interval, and arsenic trioxide carries a boxed warning for QT prolongation and torsades de pointes. Combined use raises the risk of serious ventricular arrhythmias, particularly with electrolyte disturbances.
How serious is the interaction between Arsenic trioxide and Dasatinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; if unavoidable, obtain a baseline ECG and correct potassium and magnesium before starting. Monitor ECG and electrolytes regularly throughout treatment.
What other medicines interact with Dasatinib?
MediHelp also lists interactions of Dasatinib with, for example, Saquinavir, Thioridazine, Adagrasib. The full list is on the Dasatinib page.
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