Drug interactions
Asciminib + Colchicine
Severity: Moderate
Asciminib and Colchicine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
At higher asciminib doses, inhibition of P-glycoprotein may increase colchicine exposure. Colchicine has a narrow therapeutic index, and raised levels can cause severe gastrointestinal toxicity, myelosuppression and neuromuscular toxicity.
What this interaction means in plain words
Asciminib and Colchicine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Asciminib belongs to Oncology; Colchicine belongs to Genitourinary.
Why it happens
Asciminib inhibits P-glycoprotein, reducing colchicine efflux and increasing its systemic exposure.
What to do
Monitor for colchicine toxicity and consider reducing the colchicine dose, especially at 200 mg twice daily asciminib. Use extra care in patients with renal or hepatic impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Asciminib
Other interactions of Colchicine
- Clarithromycin + Colchicine Contraindicated
- Cobicistat + Colchicine Contraindicated
- Colchicine + Cyclosporine Contraindicated
- Colchicine + Ensitrelvir Contraindicated
- Colchicine + Levoketoconazole Contraindicated
- Colchicine + Nirmatrelvir Contraindicated
Frequently asked questions
Can I take Asciminib with Colchicine?
MediHelp rates the interaction as moderate. Asciminib and Colchicine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. At higher asciminib doses, inhibition of P-glycoprotein may increase colchicine exposure. Colchicine has a narrow therapeutic index, and raised levels can cause severe gastrointestinal toxicity, myelosuppression and neuromuscular toxicity.
How serious is the interaction between Asciminib and Colchicine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for colchicine toxicity and consider reducing the colchicine dose, especially at 200 mg twice daily asciminib. Use extra care in patients with renal or hepatic impairment.
What other medicines interact with Asciminib?
MediHelp also lists interactions of Asciminib with, for example, Clarithromycin, Dihydroergotamine, Ergotamine. The full list is on the Asciminib page.
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