Drug interactions
Asciminib + Digoxin
Severity: Moderate
Asciminib and Digoxin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
At higher asciminib doses (200 mg twice daily) P-glycoprotein inhibition may increase digoxin exposure. Because digoxin has a narrow therapeutic index, this could lead to toxicity such as arrhythmias, nausea and visual disturbance.
What this interaction means in plain words
Asciminib and Digoxin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Asciminib belongs to Oncology; Digoxin belongs to Cardiovascular.
Why it happens
Asciminib inhibits intestinal and renal P-glycoprotein, reducing digoxin efflux and clearance.
What to do
Monitor serum digoxin concentrations, ECG and signs of toxicity when starting or changing asciminib, particularly at 200 mg twice daily. Reduce the digoxin dose if levels rise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Asciminib
Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Asciminib with Digoxin?
MediHelp rates the interaction as moderate. Asciminib and Digoxin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. At higher asciminib doses (200 mg twice daily) P-glycoprotein inhibition may increase digoxin exposure. Because digoxin has a narrow therapeutic index, this could lead to toxicity such as arrhythmias, nausea and visual disturbance.
How serious is the interaction between Asciminib and Digoxin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum digoxin concentrations, ECG and signs of toxicity when starting or changing asciminib, particularly at 200 mg twice daily. Reduce the digoxin dose if levels rise.
What other medicines interact with Asciminib?
MediHelp also lists interactions of Asciminib with, for example, Clarithromycin, Dihydroergotamine, Ergotamine. The full list is on the Asciminib page.
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