Drug interactions
Asciminib + Phenobarbitone
Severity: Moderate
Asciminib and Phenobarbitone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenobarbitone may lower asciminib exposure and reduce efficacy. Leukemia control may be compromised.
What this interaction means in plain words
Asciminib and Phenobarbitone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Asciminib belongs to Oncology; Phenobarbitone belongs to Central Nervous System.
Why it happens
Induction of CYP3A4 increases asciminib metabolism.
What to do
Use a non-inducing alternative where possible. If combined, monitor BCR-ABL1 response closely.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Asciminib
Other interactions of Phenobarbitone
- Cabotegravir + Phenobarbitone Contraindicated
- Doravirine + Phenobarbitone Contraindicated
- Isavuconazole + Phenobarbitone Contraindicated
- Darolutamide + Phenobarbitone Major
- Finerenone + Phenobarbitone Major
- Ivacaftor + Phenobarbitone Major
Frequently asked questions
Can I take Asciminib with Phenobarbitone?
MediHelp rates the interaction as moderate. Asciminib and Phenobarbitone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenobarbitone may lower asciminib exposure and reduce efficacy. Leukemia control may be compromised.
How serious is the interaction between Asciminib and Phenobarbitone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a non-inducing alternative where possible. If combined, monitor BCR-ABL1 response closely.
What other medicines interact with Asciminib?
MediHelp also lists interactions of Asciminib with, for example, Clarithromycin, Dihydroergotamine, Ergotamine. The full list is on the Asciminib page.
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