Drug interactions
Asenapine + Silodosin
Severity: Moderate
Asenapine and Silodosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Asenapine has alpha-1 adrenergic antagonist activity and can cause orthostatic hypotension and syncope. Combined with silodosin, the hypotensive effect may be additive.
What this interaction means in plain words
Asenapine and Silodosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Asenapine belongs to Central Nervous System; Silodosin belongs to Genitourinary.
Why it happens
Additive alpha-1 adrenergic receptor blockade.
What to do
Monitor orthostatic blood pressure when starting or adjusting either drug. Counsel patients on slow position changes and fall risk, especially older adults.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Silodosin
- Atazanavir + Silodosin Contraindicated
- Conivaptan + Silodosin Contraindicated
- Darunavir + Silodosin Contraindicated
- Fosamprenavir + Silodosin Contraindicated
- Indinavir + Silodosin Contraindicated
- Itraconazole + Silodosin Contraindicated
Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Frequently asked questions
Can I take Asenapine with Silodosin?
MediHelp rates the interaction as moderate. Asenapine and Silodosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Asenapine has alpha-1 adrenergic antagonist activity and can cause orthostatic hypotension and syncope. Combined with silodosin, the hypotensive effect may be additive.
How serious is the interaction between Asenapine and Silodosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor orthostatic blood pressure when starting or adjusting either drug. Counsel patients on slow position changes and fall risk, especially older adults.
What other medicines interact with Silodosin?
MediHelp also lists interactions of Silodosin with, for example, Atazanavir, Conivaptan, Darunavir. The full list is on the Silodosin page.
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