Drug interactions
Atazanavir + Dutasteride
Severity: Minor
Atazanavir and Dutasteride: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atazanavir inhibits CYP3A4 and can increase dutasteride concentrations. Dutasteride has a long half-life and good tolerability, so clinical impact is usually modest.
What this interaction means in plain words
Atazanavir and Dutasteride have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Atazanavir belongs to Anti Virals; Dutasteride belongs to Genitourinary.
Why it happens
Inhibition of CYP3A4-mediated dutasteride metabolism by atazanavir.
What to do
No routine dose change is needed. Watch for increased dutasteride adverse effects such as sexual dysfunction during long-term co-therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dutasteride
- Dutasteride + Levoketoconazole Moderate
- Dutasteride + Nefazodone Moderate
- Dutasteride + Rifampin Moderate
- Dutasteride + St john's wort Moderate
- Amobarbital + Dutasteride Minor
- Aprepitant + Dutasteride Minor
Other interactions of Atazanavir
- Alfuzosin + Atazanavir Contraindicated
- Atazanavir + Avanafil Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Atazanavir + Ergotamine Contraindicated
Frequently asked questions
Can I take Atazanavir with Dutasteride?
MediHelp rates the interaction as minor. Atazanavir and Dutasteride have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Atazanavir inhibits CYP3A4 and can increase dutasteride concentrations. Dutasteride has a long half-life and good tolerability, so clinical impact is usually modest.
How serious is the interaction between Atazanavir and Dutasteride?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Watch for increased dutasteride adverse effects such as sexual dysfunction during long-term co-therapy.
What other medicines interact with Dutasteride?
MediHelp also lists interactions of Dutasteride with, for example, Levoketoconazole, Nefazodone, Rifampin. The full list is on the Dutasteride page.
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