Drug interactions
Atazanavir + Montelukast
Severity: Minor
Atazanavir and Montelukast: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atazanavir inhibits CYP3A4 and may raise montelukast concentrations. Montelukast has a wide safety margin and CYP2C8 is its main route, so the effect is likely small.
What this interaction means in plain words
Atazanavir and Montelukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Atazanavir belongs to Anti Virals; Montelukast belongs to Respiratory.
Why it happens
Atazanavir inhibits CYP3A4, reducing a secondary clearance pathway of montelukast.
What to do
No dose change is usually needed. Be aware of possible increased adverse effects such as headache or neuropsychiatric symptoms.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Atazanavir and Montelukast, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Montelukast
- Apalutamide + Montelukast Moderate
- Carbamazepine + Montelukast Moderate
- Deferasirox + Montelukast Moderate
- Enzalutamide + Montelukast Moderate
- Fosphenytoin + Montelukast Moderate
- Gemfibrozil + Montelukast Moderate
Other interactions of Atazanavir
- Alfuzosin + Atazanavir Contraindicated
- Atazanavir + Avanafil Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Atazanavir + Ergotamine Contraindicated
Frequently asked questions
Can I take Atazanavir with Montelukast?
MediHelp rates the interaction as minor. Atazanavir and Montelukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Atazanavir inhibits CYP3A4 and may raise montelukast concentrations. Montelukast has a wide safety margin and CYP2C8 is its main route, so the effect is likely small.
How serious is the interaction between Atazanavir and Montelukast?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed. Be aware of possible increased adverse effects such as headache or neuropsychiatric symptoms.
What other medicines interact with Montelukast?
MediHelp also lists interactions of Montelukast with, for example, Apalutamide, Carbamazepine, Deferasirox. The full list is on the Montelukast page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
