Drug interactions
Atazanavir + Posaconazole
Severity: Moderate
Atazanavir and Posaconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are CYP3A4 substrates or inhibitors, and posaconazole can raise atazanavir levels. Atazanavir causes dose-related PR and QT prolongation and hyperbilirubinemia, and both agents have QT potential.
What this interaction means in plain words
Atazanavir and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atazanavir belongs to Anti Virals; Posaconazole belongs to Anti Fungals.
Why it happens
Inhibition of CYP3A4 metabolism of atazanavir with additive QT/PR effects.
What to do
Monitor ECG and bilirubin, and liver tests. Correct electrolytes and avoid other QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Atazanavir
- Alfuzosin + Atazanavir Contraindicated
- Atazanavir + Avanafil Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Atazanavir + Ergotamine Contraindicated
Frequently asked questions
Can I take Atazanavir with Posaconazole?
MediHelp rates the interaction as moderate. Atazanavir and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs are CYP3A4 substrates or inhibitors, and posaconazole can raise atazanavir levels. Atazanavir causes dose-related PR and QT prolongation and hyperbilirubinemia, and both agents have QT potential.
How serious is the interaction between Atazanavir and Posaconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and bilirubin, and liver tests. Correct electrolytes and avoid other QT-prolonging drugs.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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