Drug interactions
Atazanavir + Progesterone
Severity: Moderate
Atazanavir and Progesterone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atazanavir inhibits CYP3A4 and can increase progesterone concentrations. This may enhance progestogenic adverse effects such as sedation, mood change or bleeding changes.
What this interaction means in plain words
Atazanavir and Progesterone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atazanavir belongs to Anti Virals; Progesterone belongs to Endocrine.
Why it happens
Atazanavir inhibits CYP3A4-mediated progesterone metabolism.
What to do
Monitor for progestogenic adverse effects and adjust progesterone dose if needed. For contraception, consider a non-hormonal or alternative method per HIV guidance.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Progesterone
Other interactions of Atazanavir
- Alfuzosin + Atazanavir Contraindicated
- Atazanavir + Avanafil Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Atazanavir + Ergotamine Contraindicated
Frequently asked questions
Can I take Atazanavir with Progesterone?
MediHelp rates the interaction as moderate. Atazanavir and Progesterone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atazanavir inhibits CYP3A4 and can increase progesterone concentrations. This may enhance progestogenic adverse effects such as sedation, mood change or bleeding changes.
How serious is the interaction between Atazanavir and Progesterone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for progestogenic adverse effects and adjust progesterone dose if needed. For contraception, consider a non-hormonal or alternative method per HIV guidance.
What other medicines interact with Progesterone?
MediHelp also lists interactions of Progesterone with, for example, Apalutamide, Carbamazepine, Enzalutamide. The full list is on the Progesterone page.
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