Drug interactions
Atazanavir + Vilazodone
Severity: Moderate
Atazanavir and Vilazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atazanavir is a strong CYP3A4 inhibitor and can raise vilazodone exposure. This increases the risk of serotonergic and other dose-related adverse effects such as nausea, diarrhea and insomnia.
What this interaction means in plain words
Atazanavir and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atazanavir belongs to Anti Virals; Vilazodone belongs to Central Nervous System.
Why it happens
Inhibition of CYP3A4-mediated metabolism of vilazodone.
What to do
Limit the vilazodone dose to 20 mg daily during co-administration, per labeling. Monitor for adverse effects and return to the usual dose after the inhibitor is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vilazodone
- Isocarboxazid + Vilazodone Contraindicated
- Methylene blue + Vilazodone Contraindicated
- Phenelzine + Vilazodone Contraindicated
- Rasagiline + Vilazodone Contraindicated
- Selegiline transdermal + Vilazodone Contraindicated
- Selegiline + Vilazodone Contraindicated
Other interactions of Atazanavir
- Alfuzosin + Atazanavir Contraindicated
- Atazanavir + Avanafil Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Atazanavir + Ergotamine Contraindicated
Frequently asked questions
Can I take Atazanavir with Vilazodone?
MediHelp rates the interaction as moderate. Atazanavir and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atazanavir is a strong CYP3A4 inhibitor and can raise vilazodone exposure. This increases the risk of serotonergic and other dose-related adverse effects such as nausea, diarrhea and insomnia.
How serious is the interaction between Atazanavir and Vilazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit the vilazodone dose to 20 mg daily during co-administration, per labeling. Monitor for adverse effects and return to the usual dose after the inhibitor is stopped.
What other medicines interact with Vilazodone?
MediHelp also lists interactions of Vilazodone with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Vilazodone page.
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