Drug interactions
Atogepant + Fluconazole
Severity: Moderate
Atogepant and Fluconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole is a moderate CYP3A4 inhibitor and may raise atogepant exposure. This could increase adverse effects such as nausea, constipation and fatigue.
What this interaction means in plain words
Atogepant and Fluconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atogepant belongs to Central Nervous System; Fluconazole belongs to Anti Fungals.
Why it happens
Inhibition of CYP3A4-mediated metabolism of atogepant by fluconazole.
What to do
Atogepant labeling advises dose limitation with strong CYP3A4 inhibitors, and moderate inhibitors warrant attention. Monitor tolerability and consider the lower dose recommended for CYP3A4 inhibition in the product information.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Other interactions of Atogepant
- Amobarbital + Atogepant Moderate
- Apalutamide + Atogepant Moderate
- Aprepitant + Atogepant Moderate
- Armodafinil + Atogepant Moderate
- Atogepant + Bosentan Moderate
- Atogepant + Carbamazepine Moderate
Frequently asked questions
Can I take Atogepant with Fluconazole?
MediHelp rates the interaction as moderate. Atogepant and Fluconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluconazole is a moderate CYP3A4 inhibitor and may raise atogepant exposure. This could increase adverse effects such as nausea, constipation and fatigue.
How serious is the interaction between Atogepant and Fluconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Atogepant labeling advises dose limitation with strong CYP3A4 inhibitors, and moderate inhibitors warrant attention. Monitor tolerability and consider the lower dose recommended for CYP3A4 inhibition in the product information.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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