Drug interactions
Atogepant + Trazodone
Severity: Minor
Atogepant and Trazodone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trazodone is a weak CYP3A4 inhibitor at most, and atogepant is a CYP3A4 substrate. A clinically meaningful rise in atogepant levels is not expected, and the interaction is not well supported.
What this interaction means in plain words
Atogepant and Trazodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Atogepant belongs to Central Nervous System; Trazodone belongs to Central Nervous System.
Why it happens
Theoretical weak inhibition of CYP3A4 by trazodone; not an established inhibitor.
What to do
No dose change is needed; monitor for atogepant adverse effects such as nausea, constipation and somnolence.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Other interactions of Atogepant
- Amobarbital + Atogepant Moderate
- Apalutamide + Atogepant Moderate
- Aprepitant + Atogepant Moderate
- Armodafinil + Atogepant Moderate
- Atogepant + Bosentan Moderate
- Atogepant + Carbamazepine Moderate
Frequently asked questions
Can I take Atogepant with Trazodone?
MediHelp rates the interaction as minor. Atogepant and Trazodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Trazodone is a weak CYP3A4 inhibitor at most, and atogepant is a CYP3A4 substrate. A clinically meaningful rise in atogepant levels is not expected, and the interaction is not well supported.
How serious is the interaction between Atogepant and Trazodone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed; monitor for atogepant adverse effects such as nausea, constipation and somnolence.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
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