Drug interactions
Atogepant + Zileuton
Severity: Minor
Atogepant and Zileuton: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zileuton is a weak CYP3A4 inhibitor and atogepant is a CYP3A4 substrate, so atogepant exposure may rise slightly. The expected increase is modest and unlikely to be significant for most patients.
What this interaction means in plain words
Atogepant and Zileuton have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Atogepant belongs to Central Nervous System; Zileuton belongs to Respiratory.
Why it happens
Weak inhibition of CYP3A4 by zileuton reduces atogepant metabolism.
What to do
No dose adjustment is generally needed. Monitor for atogepant adverse effects such as constipation, nausea and fatigue.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Zileuton
- Fezolinetant + Zileuton Contraindicated
- Pimozide + Zileuton Contraindicated
- Alosetron + Zileuton Major
- Clozapine + Zileuton Major
- Lomitapide + Zileuton Major
- Lonafarnib + Zileuton Major
Other interactions of Atogepant
- Amobarbital + Atogepant Moderate
- Apalutamide + Atogepant Moderate
- Aprepitant + Atogepant Moderate
- Armodafinil + Atogepant Moderate
- Atogepant + Bosentan Moderate
- Atogepant + Carbamazepine Moderate
Frequently asked questions
Can I take Atogepant with Zileuton?
MediHelp rates the interaction as minor. Atogepant and Zileuton have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Zileuton is a weak CYP3A4 inhibitor and atogepant is a CYP3A4 substrate, so atogepant exposure may rise slightly. The expected increase is modest and unlikely to be significant for most patients.
How serious is the interaction between Atogepant and Zileuton?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is generally needed. Monitor for atogepant adverse effects such as constipation, nausea and fatigue.
What other medicines interact with Zileuton?
MediHelp also lists interactions of Zileuton with, for example, Fezolinetant, Pimozide, Alosetron. The full list is on the Zileuton page.
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