Drug interactions
Atropine + Chlorpromazine
Severity: Moderate
Atropine and Chlorpromazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have anticholinergic activity, so combining them can increase dry mouth, constipation, urinary retention, blurred vision, confusion and tachycardia. Atropine may also reduce oral chlorpromazine absorption and gastrointestinal motility changes can worsen constipation or ileus.
What this interaction means in plain words
Atropine and Chlorpromazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atropine belongs to Miscellaneous; Chlorpromazine belongs to Central Nervous System.
Why it happens
Additive antimuscarinic effects, with possible reduced chlorpromazine absorption from slowed gastric motility.
What to do
Monitor for anticholinergic toxicity, especially in older patients, and check for reduced antipsychotic effect. Reduce doses or choose alternatives if delirium, urinary retention or ileus develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Other interactions of Atropine
- Atropine + Eluxadoline Major
- Atropine + Henbane Major
- Atropine + Pramlintide Major
- Abobotulinumtoxina + Atropine Moderate
- Aclidinium + Atropine Moderate
- Amantadine + Atropine Moderate
Frequently asked questions
Can I take Atropine with Chlorpromazine?
MediHelp rates the interaction as moderate. Atropine and Chlorpromazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have anticholinergic activity, so combining them can increase dry mouth, constipation, urinary retention, blurred vision, confusion and tachycardia. Atropine may also reduce oral chlorpromazine absorption and gastrointestinal motility changes can worsen constipation or ileus.
How serious is the interaction between Atropine and Chlorpromazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity, especially in older patients, and check for reduced antipsychotic effect. Reduce doses or choose alternatives if delirium, urinary retention or ileus develops.
What other medicines interact with Chlorpromazine?
MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.
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