Drug interactions
Atropine + Metoclopramide
Severity: Moderate
Atropine and Metoclopramide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atropine has antimuscarinic effects that slow gastric motility and directly oppose the prokinetic action of metoclopramide. The therapeutic effect of metoclopramide may be diminished.
What this interaction means in plain words
Atropine and Metoclopramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atropine belongs to Miscellaneous; Metoclopramide belongs to Gastrointestinal Tract.
Why it happens
Pharmacodynamic antagonism: anticholinergic blockade opposes cholinergic prokinetic effects of metoclopramide.
What to do
Monitor for reduced prokinetic or antiemetic response. Avoid the combination when gastric emptying is the treatment goal, or choose a different agent.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metoclopramide
Other interactions of Atropine
- Atropine + Eluxadoline Major
- Atropine + Henbane Major
- Atropine + Pramlintide Major
- Abobotulinumtoxina + Atropine Moderate
- Aclidinium + Atropine Moderate
- Amantadine + Atropine Moderate
Frequently asked questions
Can I take Atropine with Metoclopramide?
MediHelp rates the interaction as moderate. Atropine and Metoclopramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atropine has antimuscarinic effects that slow gastric motility and directly oppose the prokinetic action of metoclopramide. The therapeutic effect of metoclopramide may be diminished.
How serious is the interaction between Atropine and Metoclopramide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced prokinetic or antiemetic response. Avoid the combination when gastric emptying is the treatment goal, or choose a different agent.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
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