Drug interactions
Atropine + Prochlorperazine
Severity: Moderate
Atropine and Prochlorperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have antimuscarinic activity, so combining them increases dry mouth, constipation, urinary retention, blurred vision and confusion. Heat intolerance from reduced sweating and tachycardia may also occur, especially in older adults.
What this interaction means in plain words
Atropine and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atropine belongs to Miscellaneous; Prochlorperazine belongs to Central Nervous System.
Why it happens
Additive anticholinergic effects from muscarinic receptor blockade.
What to do
Monitor for anticholinergic toxicity, especially in older patients, and use the lowest effective doses; avoid in narrow-angle glaucoma or urinary obstruction.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Other interactions of Atropine
- Atropine + Eluxadoline Major
- Atropine + Henbane Major
- Atropine + Pramlintide Major
- Abobotulinumtoxina + Atropine Moderate
- Aclidinium + Atropine Moderate
- Amantadine + Atropine Moderate
Frequently asked questions
Can I take Atropine with Prochlorperazine?
MediHelp rates the interaction as moderate. Atropine and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have antimuscarinic activity, so combining them increases dry mouth, constipation, urinary retention, blurred vision and confusion. Heat intolerance from reduced sweating and tachycardia may also occur, especially in older adults.
How serious is the interaction between Atropine and Prochlorperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity, especially in older patients, and use the lowest effective doses; avoid in narrow-angle glaucoma or urinary obstruction.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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