Drug interactions
Avanafil + Azilsartan-chlorthalidone
Severity: Moderate
Avanafil and Azilsartan-chlorthalidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Avanafil is a PDE5 inhibitor with vasodilating effects that can add to the blood pressure lowering effects of azilsartan and chlorthalidone. Symptomatic hypotension may occur, particularly in volume-depleted patients.
What this interaction means in plain words
Avanafil and Azilsartan-chlorthalidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avanafil belongs to Genitourinary; Azilsartan-chlorthalidone belongs to Cardiovascular.
Why it happens
Additive vasodilation from PDE5 inhibition and antihypertensive therapy.
What to do
Start with the lowest avanafil dose and monitor blood pressure and orthostatic symptoms. Do not use with nitrates.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azilsartan-chlorthalidone
Other interactions of Avanafil
- Amyl nitrite + Avanafil Contraindicated
- Atazanavir + Avanafil Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Avanafil + Conivaptan Contraindicated
- Avanafil + Darunavir Contraindicated
- Avanafil + Fosamprenavir Contraindicated
Frequently asked questions
Can I take Avanafil with Azilsartan-chlorthalidone?
MediHelp rates the interaction as moderate. Avanafil and Azilsartan-chlorthalidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Avanafil is a PDE5 inhibitor with vasodilating effects that can add to the blood pressure lowering effects of azilsartan and chlorthalidone. Symptomatic hypotension may occur, particularly in volume-depleted patients.
How serious is the interaction between Avanafil and Azilsartan-chlorthalidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with the lowest avanafil dose and monitor blood pressure and orthostatic symptoms. Do not use with nitrates.
What other medicines interact with Azilsartan-chlorthalidone?
MediHelp also lists interactions of Azilsartan-chlorthalidone with, for example, Aliskiren, Sparsentan, Aceclofenac. The full list is on the Azilsartan-chlorthalidone page.
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