Drug interactions
Avanafil + Azilsartan
Severity: Moderate
Avanafil and Azilsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Avanafil can add to the antihypertensive effect of angiotensin receptor blockers. Patients may experience lightheadedness or symptomatic hypotension, especially when volume depleted.
What this interaction means in plain words
Avanafil and Azilsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avanafil belongs to Genitourinary; Azilsartan belongs to Cardiovascular.
Why it happens
Additive vasodilation from PDE5 inhibition and angiotensin II receptor blockade.
What to do
Start avanafil at a low dose in patients on stable azilsartan therapy. Monitor blood pressure and advise on orthostatic symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Avanafil
- Amyl nitrite + Avanafil Contraindicated
- Atazanavir + Avanafil Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Avanafil + Conivaptan Contraindicated
- Avanafil + Darunavir Contraindicated
- Avanafil + Fosamprenavir Contraindicated
Other interactions of Azilsartan
- Aliskiren + Azilsartan Contraindicated
- Azilsartan + Sparsentan Contraindicated
- Amifostine + Azilsartan Major
- Amlodipine-benazepril + Azilsartan Major
- Amlodipine-perindopril + Azilsartan Major
- Azilsartan + Benazepril Major
Frequently asked questions
Can I take Avanafil with Azilsartan?
MediHelp rates the interaction as moderate. Avanafil and Azilsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Avanafil can add to the antihypertensive effect of angiotensin receptor blockers. Patients may experience lightheadedness or symptomatic hypotension, especially when volume depleted.
How serious is the interaction between Avanafil and Azilsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start avanafil at a low dose in patients on stable azilsartan therapy. Monitor blood pressure and advise on orthostatic symptoms.
What other medicines interact with Avanafil?
MediHelp also lists interactions of Avanafil with, for example, Amyl nitrite, Atazanavir, Clarithromycin. The full list is on the Avanafil page.
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