Drug interactions
Avanafil + Benazepril
Severity: Moderate
Avanafil and Benazepril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Avanafil may potentiate the blood pressure lowering of ACE inhibitors. This can cause dizziness or symptomatic hypotension, particularly at treatment initiation.
What this interaction means in plain words
Avanafil and Benazepril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avanafil belongs to Genitourinary; Benazepril belongs to Cardiovascular.
Why it happens
Additive vasodilation from PDE5 inhibition and ACE inhibition.
What to do
Confirm blood pressure is controlled and start avanafil at a low dose. Monitor blood pressure and counsel on postural symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Avanafil
- Amyl nitrite + Avanafil Contraindicated
- Atazanavir + Avanafil Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Avanafil + Conivaptan Contraindicated
- Avanafil + Darunavir Contraindicated
- Avanafil + Fosamprenavir Contraindicated
Other interactions of Benazepril
- Aliskiren + Benazepril Contraindicated
- Benazepril + Sacubitril / valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Amifostine + Benazepril Major
- Amiloride + Benazepril Major
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Major
Frequently asked questions
Can I take Avanafil with Benazepril?
MediHelp rates the interaction as moderate. Avanafil and Benazepril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Avanafil may potentiate the blood pressure lowering of ACE inhibitors. This can cause dizziness or symptomatic hypotension, particularly at treatment initiation.
How serious is the interaction between Avanafil and Benazepril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Confirm blood pressure is controlled and start avanafil at a low dose. Monitor blood pressure and counsel on postural symptoms.
What other medicines interact with Avanafil?
MediHelp also lists interactions of Avanafil with, for example, Amyl nitrite, Atazanavir, Clarithromycin. The full list is on the Avanafil page.
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