Drug interactions
Avanafil + Bosentan
Severity: Moderate
Avanafil and Bosentan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosentan is a moderate CYP3A4 inducer and may lower avanafil exposure. This can reduce erectile response to avanafil.
What this interaction means in plain words
Avanafil and Bosentan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avanafil belongs to Genitourinary; Bosentan belongs to Miscellaneous.
Why it happens
Bosentan induces CYP3A4, increasing the metabolism of avanafil.
What to do
Monitor erectile response and consider an alternative PDE5 inhibitor or dose adjustment if efficacy is inadequate. Do not exceed the labeled maximum avanafil dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Avanafil
- Amyl nitrite + Avanafil Contraindicated
- Atazanavir + Avanafil Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Avanafil + Conivaptan Contraindicated
- Avanafil + Darunavir Contraindicated
- Avanafil + Fosamprenavir Contraindicated
Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Frequently asked questions
Can I take Avanafil with Bosentan?
MediHelp rates the interaction as moderate. Avanafil and Bosentan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bosentan is a moderate CYP3A4 inducer and may lower avanafil exposure. This can reduce erectile response to avanafil.
How serious is the interaction between Avanafil and Bosentan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor erectile response and consider an alternative PDE5 inhibitor or dose adjustment if efficacy is inadequate. Do not exceed the labeled maximum avanafil dose.
What other medicines interact with Avanafil?
MediHelp also lists interactions of Avanafil with, for example, Amyl nitrite, Atazanavir, Clarithromycin. The full list is on the Avanafil page.
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