Drug interactions
Avanafil + Captopril-hydrochlorothiazide
Severity: Moderate
Avanafil and Captopril-hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Avanafil is a PDE5 inhibitor with vasodilating effects that can add to the blood pressure lowering of captopril and hydrochlorothiazide. Symptomatic hypotension, dizziness or syncope may occur.
What this interaction means in plain words
Avanafil and Captopril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avanafil belongs to Genitourinary; Captopril-hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Additive vasodilation from PDE5 inhibition with ACE inhibition and diuretic-related volume reduction.
What to do
Start avanafil at the lowest dose and monitor blood pressure and symptoms. Advise patients to rise slowly and avoid use if volume-depleted.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Other interactions of Avanafil
- Amyl nitrite + Avanafil Contraindicated
- Atazanavir + Avanafil Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Avanafil + Conivaptan Contraindicated
- Avanafil + Darunavir Contraindicated
- Avanafil + Fosamprenavir Contraindicated
Frequently asked questions
Can I take Avanafil with Captopril-hydrochlorothiazide?
MediHelp rates the interaction as moderate. Avanafil and Captopril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Avanafil is a PDE5 inhibitor with vasodilating effects that can add to the blood pressure lowering of captopril and hydrochlorothiazide. Symptomatic hypotension, dizziness or syncope may occur.
How serious is the interaction between Avanafil and Captopril-hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start avanafil at the lowest dose and monitor blood pressure and symptoms. Advise patients to rise slowly and avoid use if volume-depleted.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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