Drug interactions
Avanafil + Cimetidine
Severity: Moderate
Avanafil and Cimetidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cimetidine, a moderate-to-weak CYP3A4 inhibitor, may increase avanafil exposure. This raises the risk of hypotension, headache, flushing and priapism.
What this interaction means in plain words
Avanafil and Cimetidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avanafil belongs to Genitourinary; Cimetidine belongs to Gastrointestinal Tract.
Why it happens
Cimetidine inhibits CYP3A4, reducing avanafil clearance.
What to do
Limit avanafil to 50 mg no more than once every 24 hours if a moderate CYP3A4 inhibitor is considered applicable. Monitor for hypotension and counsel on priapism.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cimetidine
- Cimetidine + Dofetilide Contraindicated
- Cimetidine + Fezolinetant Contraindicated
- Alfentanil + Cimetidine Major
- Atazanavir + Cimetidine Major
- Carmustine + Cimetidine Major
- Cimetidine + Citalopram Major
Other interactions of Avanafil
- Amyl nitrite + Avanafil Contraindicated
- Atazanavir + Avanafil Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Avanafil + Conivaptan Contraindicated
- Avanafil + Darunavir Contraindicated
- Avanafil + Fosamprenavir Contraindicated
Frequently asked questions
Can I take Avanafil with Cimetidine?
MediHelp rates the interaction as moderate. Avanafil and Cimetidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cimetidine, a moderate-to-weak CYP3A4 inhibitor, may increase avanafil exposure. This raises the risk of hypotension, headache, flushing and priapism.
How serious is the interaction between Avanafil and Cimetidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit avanafil to 50 mg no more than once every 24 hours if a moderate CYP3A4 inhibitor is considered applicable. Monitor for hypotension and counsel on priapism.
What other medicines interact with Cimetidine?
MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Fezolinetant, Alfentanil. The full list is on the Cimetidine page.
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