Drug interactions
Avanafil + Clotrimazole
Severity: Minor
Avanafil and Clotrimazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic clotrimazole exposure is generally low with topical use, but oral lozenge or vaginal use can produce some CYP3A4 inhibition. Elevated avanafil levels could increase adverse effects such as hypotension, headache and flushing.
What this interaction means in plain words
Avanafil and Clotrimazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Avanafil belongs to Genitourinary; Clotrimazole belongs to Anti Fungals.
Why it happens
Clotrimazole may weakly inhibit CYP3A4, reducing avanafil clearance.
What to do
No change is needed for topical use. With prolonged oral lozenge use, keep avanafil at or below 50 mg per 24 hours and monitor for adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Avanafil
- Amyl nitrite + Avanafil Contraindicated
- Atazanavir + Avanafil Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Avanafil + Conivaptan Contraindicated
- Avanafil + Darunavir Contraindicated
- Avanafil + Fosamprenavir Contraindicated
Other interactions of Clotrimazole
- Clotrimazole + Lomitapide Major
- Clotrimazole + Mavacamten Major
- Clotrimazole + Mobocertinib Major
- Clotrimazole + Voclosporin Major
- Bosutinib + Clotrimazole Moderate
- Cannabidiol + Clotrimazole Moderate
Frequently asked questions
Can I take Avanafil with Clotrimazole?
MediHelp rates the interaction as minor. Avanafil and Clotrimazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Systemic clotrimazole exposure is generally low with topical use, but oral lozenge or vaginal use can produce some CYP3A4 inhibition. Elevated avanafil levels could increase adverse effects such as hypotension, headache and flushing.
How serious is the interaction between Avanafil and Clotrimazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No change is needed for topical use. With prolonged oral lozenge use, keep avanafil at or below 50 mg per 24 hours and monitor for adverse effects.
What other medicines interact with Avanafil?
MediHelp also lists interactions of Avanafil with, for example, Amyl nitrite, Atazanavir, Clarithromycin. The full list is on the Avanafil page.
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