Drug interactions
Avanafil + Felodipine
Severity: Moderate
Avanafil and Felodipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
PDE5 inhibition by avanafil adds vasodilation to that of the calcium channel blocker felodipine. This can produce additive blood pressure reduction with dizziness or symptomatic hypotension.
What this interaction means in plain words
Avanafil and Felodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avanafil belongs to Genitourinary; Felodipine belongs to Cardiovascular.
Why it happens
Additive vasodilatory and hypotensive effects (pharmacodynamic synergism).
What to do
Check that blood pressure is stable on felodipine before starting avanafil, and monitor for orthostatic symptoms after initiation. Start at the lowest dose of avanafil.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Avanafil
- Amyl nitrite + Avanafil Contraindicated
- Atazanavir + Avanafil Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Avanafil + Conivaptan Contraindicated
- Avanafil + Darunavir Contraindicated
- Avanafil + Fosamprenavir Contraindicated
Other interactions of Felodipine
- Felodipine + Itraconazole Contraindicated
- Aldesleukin + Felodipine Major
- Amifostine + Felodipine Major
- Apalutamide + Felodipine Major
- Atazanavir + Felodipine Major
- Carbamazepine + Felodipine Major
Frequently asked questions
Can I take Avanafil with Felodipine?
MediHelp rates the interaction as moderate. Avanafil and Felodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. PDE5 inhibition by avanafil adds vasodilation to that of the calcium channel blocker felodipine. This can produce additive blood pressure reduction with dizziness or symptomatic hypotension.
How serious is the interaction between Avanafil and Felodipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check that blood pressure is stable on felodipine before starting avanafil, and monitor for orthostatic symptoms after initiation. Start at the lowest dose of avanafil.
What other medicines interact with Avanafil?
MediHelp also lists interactions of Avanafil with, for example, Amyl nitrite, Atazanavir, Clarithromycin. The full list is on the Avanafil page.
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