Drug interactions
Avanafil + Fosinopril-hydrochlorothiazide
Severity: Moderate
Avanafil and Fosinopril-hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Avanafil is a PDE5 inhibitor that causes vasodilation and can lower blood pressure. When used with an ACE inhibitor and thiazide, the effect can be additive, with symptomatic hypotension, dizziness or syncope.
What this interaction means in plain words
Avanafil and Fosinopril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avanafil belongs to Genitourinary; Fosinopril-hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Additive vasodilation through PDE5 inhibition combined with antihypertensive therapy.
What to do
Counsel patients to rise slowly and report dizziness. Ensure blood pressure is stable before starting avanafil and use the lowest effective dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fosinopril-hydrochlorothiazide
- Aliskiren + Fosinopril-hydrochlorothiazide Contraindicated
- Dofetilide + Fosinopril-hydrochlorothiazide Contraindicated
- Fosinopril-hydrochlorothiazide + Protein a column Contraindicated
- Fosinopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aldesleukin + Fosinopril-hydrochlorothiazide Major
- Amifostine + Fosinopril-hydrochlorothiazide Major
Other interactions of Avanafil
- Amyl nitrite + Avanafil Contraindicated
- Atazanavir + Avanafil Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Avanafil + Conivaptan Contraindicated
- Avanafil + Darunavir Contraindicated
- Avanafil + Fosamprenavir Contraindicated
Frequently asked questions
Can I take Avanafil with Fosinopril-hydrochlorothiazide?
MediHelp rates the interaction as moderate. Avanafil and Fosinopril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Avanafil is a PDE5 inhibitor that causes vasodilation and can lower blood pressure. When used with an ACE inhibitor and thiazide, the effect can be additive, with symptomatic hypotension, dizziness or syncope.
How serious is the interaction between Avanafil and Fosinopril-hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to rise slowly and report dizziness. Ensure blood pressure is stable before starting avanafil and use the lowest effective dose.
What other medicines interact with Fosinopril-hydrochlorothiazide?
MediHelp also lists interactions of Fosinopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Fosinopril-hydrochlorothiazide page.
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