Drug interactions
Avanafil + Mifepristone
Severity: Moderate
Avanafil and Mifepristone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone inhibits CYP3A4 and may raise avanafil concentrations, increasing hypotension and other PDE5 adverse effects. Avanafil is sensitive to CYP3A4 inhibition.
What this interaction means in plain words
Avanafil and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avanafil belongs to Genitourinary; Mifepristone belongs to Endocrine.
Why it happens
Inhibition of CYP3A4-mediated avanafil metabolism.
What to do
Use the lowest avanafil dose and monitor blood pressure and adverse effects. Avoid if the patient is also taking other CYP3A4 inhibitors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Avanafil
- Amyl nitrite + Avanafil Contraindicated
- Atazanavir + Avanafil Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Avanafil + Conivaptan Contraindicated
- Avanafil + Darunavir Contraindicated
- Avanafil + Fosamprenavir Contraindicated
Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Frequently asked questions
Can I take Avanafil with Mifepristone?
MediHelp rates the interaction as moderate. Avanafil and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mifepristone inhibits CYP3A4 and may raise avanafil concentrations, increasing hypotension and other PDE5 adverse effects. Avanafil is sensitive to CYP3A4 inhibition.
How serious is the interaction between Avanafil and Mifepristone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest avanafil dose and monitor blood pressure and adverse effects. Avoid if the patient is also taking other CYP3A4 inhibitors.
What other medicines interact with Avanafil?
MediHelp also lists interactions of Avanafil with, for example, Amyl nitrite, Atazanavir, Clarithromycin. The full list is on the Avanafil page.
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