Drug interactions
Avanafil + Vardenafil
Severity: Major
Avanafil and Vardenafil: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are PDE5 inhibitors, so using them together duplicates therapy and increases the risk of hypotension, priapism, headache and visual disturbances with no added benefit.
What this interaction means in plain words
Avanafil and Vardenafil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Avanafil belongs to Genitourinary; Vardenafil belongs to Genitourinary.
Why it happens
Duplicate PDE5 inhibition produces additive pharmacodynamic effects.
What to do
Do not use two PDE5 inhibitors concurrently. Choose a single agent and titrate it to the lowest effective dose.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Vardenafil
- Amyl nitrite + Vardenafil Contraindicated
- Glyceryl trinitrate pr + Vardenafil Contraindicated
- Isosorbide dinitrate + Vardenafil Contraindicated
- Isosorbide mononitrate + Vardenafil Contraindicated
- Nicorandil + Vardenafil Contraindicated
- Nitroglycerin po + Vardenafil Contraindicated
Other interactions of Avanafil
- Amyl nitrite + Avanafil Contraindicated
- Atazanavir + Avanafil Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Avanafil + Conivaptan Contraindicated
- Avanafil + Darunavir Contraindicated
- Avanafil + Fosamprenavir Contraindicated
Frequently asked questions
Can I take Avanafil with Vardenafil?
MediHelp rates the interaction as major. Avanafil and Vardenafil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both are PDE5 inhibitors, so using them together duplicates therapy and increases the risk of hypotension, priapism, headache and visual disturbances with no added benefit.
How serious is the interaction between Avanafil and Vardenafil?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use two PDE5 inhibitors concurrently. Choose a single agent and titrate it to the lowest effective dose.
What other medicines interact with Vardenafil?
MediHelp also lists interactions of Vardenafil with, for example, Amyl nitrite, Glyceryl trinitrate pr, Isosorbide dinitrate. The full list is on the Vardenafil page.
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