Drug interactions
Avanafil + Verapamil
Severity: Moderate
Avanafil and Verapamil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Verapamil is a moderate CYP3A4 inhibitor and can reduce the clearance of avanafil, raising its systemic exposure. This may intensify vasodilatory adverse effects such as hypotension, flushing, headache and dizziness, which is particularly relevant because verapamil also lowers blood pressure.
What this interaction means in plain words
Avanafil and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avanafil belongs to Genitourinary; Verapamil belongs to Cardiovascular.
Why it happens
Verapamil inhibits intestinal and hepatic CYP3A4, decreasing the first-pass and systemic metabolism of avanafil.
What to do
Limit avanafil to a maximum of 50 mg, no more often than once every 24 hours, while verapamil is taken. Monitor blood pressure and symptoms of hypotension.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Avanafil
- Amyl nitrite + Avanafil Contraindicated
- Atazanavir + Avanafil Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Avanafil + Conivaptan Contraindicated
- Avanafil + Darunavir Contraindicated
- Avanafil + Fosamprenavir Contraindicated
Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Frequently asked questions
Can I take Avanafil with Verapamil?
MediHelp rates the interaction as moderate. Avanafil and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Verapamil is a moderate CYP3A4 inhibitor and can reduce the clearance of avanafil, raising its systemic exposure. This may intensify vasodilatory adverse effects such as hypotension, flushing, headache and dizziness, which is particularly relevant because verapamil also lowers blood pressure.
How serious is the interaction between Avanafil and Verapamil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit avanafil to a maximum of 50 mg, no more often than once every 24 hours, while verapamil is taken. Monitor blood pressure and symptoms of hypotension.
What other medicines interact with Avanafil?
MediHelp also lists interactions of Avanafil with, for example, Amyl nitrite, Atazanavir, Clarithromycin. The full list is on the Avanafil page.
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