Drug interactions
Avanafil + Voxelotor
Severity: Moderate
Avanafil and Voxelotor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voxelotor can raise exposure to drugs cleared by CYP3A4. Avanafil is a sensitive CYP3A4 substrate, so its levels and its effects, including hypotension, flushing, headache and priapism, may increase.
What this interaction means in plain words
Avanafil and Voxelotor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avanafil belongs to Genitourinary; Voxelotor belongs to Miscellaneous.
Why it happens
Voxelotor inhibits intestinal and hepatic CYP3A4, reducing the metabolism of avanafil.
What to do
Start with the lowest avanafil dose and do not exceed it. Monitor for hypotension and prolonged erections, and counsel the patient to seek care if an erection lasts longer than 4 hours.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Avanafil
- Amyl nitrite + Avanafil Contraindicated
- Atazanavir + Avanafil Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Avanafil + Conivaptan Contraindicated
- Avanafil + Darunavir Contraindicated
- Avanafil + Fosamprenavir Contraindicated
Other interactions of Voxelotor
- Amobarbital + Voxelotor Major
- Apalutamide + Voxelotor Major
- Carbamazepine + Voxelotor Major
- Cyclosporin + Voxelotor Major
- Efavirenz + Voxelotor Major
- Enzalutamide + Voxelotor Major
Frequently asked questions
Can I take Avanafil with Voxelotor?
MediHelp rates the interaction as moderate. Avanafil and Voxelotor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voxelotor can raise exposure to drugs cleared by CYP3A4. Avanafil is a sensitive CYP3A4 substrate, so its levels and its effects, including hypotension, flushing, headache and priapism, may increase.
How serious is the interaction between Avanafil and Voxelotor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with the lowest avanafil dose and do not exceed it. Monitor for hypotension and prolonged erections, and counsel the patient to seek care if an erection lasts longer than 4 hours.
What other medicines interact with Avanafil?
MediHelp also lists interactions of Avanafil with, for example, Amyl nitrite, Atazanavir, Clarithromycin. The full list is on the Avanafil page.
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