Drug interactions
Avapritinib + Dantrolene
Severity: Moderate
Avapritinib and Dantrolene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Avapritinib can cause cognitive effects and somnolence, and dantrolene is sedating. Together they may worsen drowsiness and cognitive impairment.
What this interaction means in plain words
Avapritinib and Dantrolene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avapritinib belongs to Oncology; Dantrolene belongs to Musculoskeletal.
Why it happens
Additive central nervous system effects; the avapritinib contribution is not fully characterized.
What to do
Monitor for sedation and cognitive changes, and counsel regarding driving. Reduce or interrupt avapritinib per labeling if neurocognitive effects emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dantrolene
Other interactions of Avapritinib
Frequently asked questions
Can I take Avapritinib with Dantrolene?
MediHelp rates the interaction as moderate. Avapritinib and Dantrolene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Avapritinib can cause cognitive effects and somnolence, and dantrolene is sedating. Together they may worsen drowsiness and cognitive impairment.
How serious is the interaction between Avapritinib and Dantrolene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and cognitive changes, and counsel regarding driving. Reduce or interrupt avapritinib per labeling if neurocognitive effects emerge.
What other medicines interact with Dantrolene?
MediHelp also lists interactions of Dantrolene with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Dantrolene page.
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